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"progeria" - naadrevi dabereba
"progeria" - naadrevi dabereba
12:20 11.04.2011 [nino kochlamazashvili]

esaa,  yvelaze sashineli daavadeba, romelic ganukurnebelia da dziritadad emartebat patara, yvelaze sayvarel da umanko arsebebs - bavshvebs.

hatchinson-gilfordis (Hutchinson–Gilford) sindromi anu progeria esaa daavadeba romelic gamoixateba naadrev asakshi daberebit. tviton sityva "progeria" momdinareobs berdznuli progeros-dan rac nishnavs naadrevad moxucs. dzalian ishviati daavadebaa, igi gvxvdeba 8 milionidan ert shemtxvevashi. progeriit dabadebulebi cxovroben dziritadad 13 weli, tumca yofila shemtxveva ormoc wlamde ecocxlot.

progeria pirvelad aghwera jonatan hatchinsonma 1886 wels, xolo 1897 wels - hastings gilfordma. daavadebas shemdgom ewoda hatchinson-gilfordis progeriis sindromi (HGPS). progeriit "daavadebuli" bavshvebi dabadebidan 6-12 tvis ganmavlobashi chveulebrivad, normalurad vitardebian. dabadebidan 1 wlis shemdeg ki tavs ichens siberistvis damaxasiatebeli simptomebi: naochdeba kani, ar vitardeba dzvlovani sistema, pataraa saxe, yba, cxviri; aqvt iseti myife organoebi, rogorc moxucebs. scvivat tma, uqveitdebat mxedveloba, chndeba sisxldzarghvta problemebi. dabereba imdenad chqardeba, rom rva wlis bavshvi garegnulad 80 wlis moxucs emsgavseba. progeriit daavadebuli adamianebi dzalian hgvanan ertmanets.

klasikuri hitchon-gilfordis progeriis sindromi, shvils mshoblisgan ar gadaecema, tavad daavadebulebi ki ver cocxloben imdeni xani, rom sakutari shvilebi iyolion... "daavadeba" gamowveulia shemtxveviti mutaciit, embrionis ganvitarebis adreul stadiaze. bolodroindeli gamokvlevebit damtkicda, rom progeria esaa romelime genis mutaciis shedegi, ris gamoc adamianis biologiur-fizikuri ganvitareba dachqarebulia daaxloebit 50-100-jer.

hitchon-gilfordis progeriis sindromitaa daavadebuli 12 wlis set kuki, igi otxmoci wlis adamianivit gamoiyureba. ar aqvs tma, awuxebs is daavadeba, romlebitac moxucebi itanjebian, amitom bichuna yoveldghe ighebs aspirinsa da sisxlis gamatxelebel sxva preparatebs. ert metrze odnav meti simaghlis mozardi daaxloebit 12 kilograms iwonis.

arsebobs progeriis meore saxe, verneris sindromi. simptomebi igivea, ubralod gvian vlindeba, sqesobrivi momwifebis periodshi da adamianma shesadzloa 30-40 wels miaghwios.

verneris sindromis shemtxvevashi, swraf daberebas tan axlavs aterosklerozi, diabeti, kataraqtis adreuli ganvitareba. am patologiit daavadebuli adamianebi 17-18 wlamde normalurad vitardebian, shemdeg ki elviseburi siswrafit berdebian. dzalian ishviatad, tumca yofila shemtxveva rom daavadebuls 50 wlamde ucocxlia.

verneris sindromit iyo daavadebuli inglisis lordis, graf uiliam shefildis vaji tomi. 16 wlamde tomi chveulebrivi sicocxlitsavse bichi iyo, shemdgomi ori wlis ganmavlobashi ki ise sheicvala, rom 50 wlis mamaze gacilebit ufrosad gamoyureboda. igi maleve gardaicvala...

diagnozis dasma xdeba daavadebis simptomebis gamovlenis shemdeg, genetikuri testis meshveobit.

mecnierebi cdiloben amoxsnan es fenomeni, tumca imedismomcem shedegebs ver idzlevian. daadgines mxolod is, rom progeria esaa genis mutaciis shedegi, dabereba xdeba chveulebrivze 100-jer swrafad. "damnashave" genis gakontroleba ki mecnierebs jerjerobit ar sheudzliat.

gankurnebis gzas ver miakvlies. yvela mkurnaloba mimartulia rigi gartulebebis shesamcireblad. daavadebulta 90% ighupeba gulisshetevita da insultit. amjamad msoflioshi dafiqsirebulia 35-40 shemtxveva.


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